There's no smoking marijuana use is mentioned in a flashback and there's little sexual content beyond flirting and kissing. All the characters drink socially, including to excess on a few occasions. Although it's not marketed as a young adult book, it has teen appeal, and it's been adapted into a film that many teens will see. The two main characters learn a lot from each other, especially about opening yourself up to different ways of thinking, but many - especially in the disabled community - have found the portrayal of Will and his point of view problematic, since he's presented as feeling that life isn't worth living if you're disabled.
Will is facing a serious decision about his condition, and Lou, his hired caregiver, tries her best to get him to make the choice everyone else wants. Parents need to know that Me Before You is about an unlikely relationship between Louisa, a working-class British woman, and Will, a quadriplegic living at his wealthy parents' estate.